I been debating which one to use on my BC and small BC mix for ticks as well as prevention of Mites, which seem to increase in numbers with the ever increasing number of Coyotes we see these days. Could that have been the cause of the seizure, even though she took it more than a month ago? Their treatment for this was nexgard and medicated baths. After a single administration of 5 times the maximum recommended dose to this sensitive dog breed, transient 3,4,7-9 Most notably, a series of randomized . We need more people like you. Turns out it is also used for the treatment and prevention of roundworms and lungworm nemotodes in dogs, according to Vet Shop Max. I did some digging, and from what Ive read it sounds like just one report would be considered anecdotal and would not be considered evidence that Seresto could cause seizures, but if there are 2 or more reports then the company might be obliged by the EPA to add a potential seizure warning to its label or possibly to do more clinical safety research. These can come in a few different forms: monthly spot-on, a disposable collar, or a spray. 5 A dog's reaction to flea bites may vary from sores and inflammation to hair loss. I was unaware of MDR1 Mutation drug reactions at the time. The drug must be given daily and if more than two days are missed the risk of heartworm infection is significant.. I gave a mini aussie and a minnie aussie/border collie mix. (Just bear in mind that Preventic contains amitraz, which is toxic to cats.). If you are able to keep your dogs separated from your cats for 24hrs, the added protection against mosquitoes that K9 Advantix II provides from the possible diseases they carry seems like a greater pro to con ratio. , I use Advecta 3 because it prevents and kills I have been in the dog Bussiness for over 26 years and used to use frontline bit past few years switched because frontline doesnt prevent .I never had a problem with advecta 3 and hope its safe, As this is a Collie blog and I assume the majority of people who read this post have a Collie, Im just hesitant to recommend it since many Collies have issues with sensitive skin even if theyre clear of MDR1. If you have one of those rare dogs who is just going to react to every heartworm medication (fingers and toes crossed thats not the case), then you might want to consider frequent heartworm tests as an alternative to regular heartworm treatment. (Most vets are going to recommend to you the products they carry in stock, but you can order online from Chewy or pet pharmacies.) How can I prevent my dog from getting ticks? It is the first drug that combined three active ingredients - sarolaner, moxidectin, and pyrantel. SIMPARICA TRIO tested positive for heartworm disease. The Whole Dog Journal points out that oral flea-control medications have been proven to be more effective than topical pesticides in both killing fleas and helping to control a household infestation more quickly. While this is true, the benefit of topical treatments is in their general safety. Although it would be very hard to determine exactly which component of a combination medication your Collie is reacting to, your girl might be less likely to have a reaction to Interceptor (regular, not Plus), as it only has one active ingredient as opposed to the two active ingredients in Sentinel. The vet thought he would be nice and put Advantage Multi on our cats. She has always had a sensitive stomach, but as she gets older, it gets worse. Super useful research. The bottom line is, its best to avoid giving your Collie Heartgard or a similar medication. The main goal of this medication, according to the FDA, is; Simparica TRIO contains three active pharmaceutical ingredients, sarolaner, moxidectin, and pyrantel pamoate. This article from Your Dog Advisor gives more natural prevention options and even tells you how to mix your own parasite preventives using essential oils and water. The drawback of Advantage is that it does not offer any protection against ticks. Freckles my Aussie/Pyr is such a great dog. A negative heartworm test is crucial prior to beginning administration of diethylcarbamazine. . ? If your Border Collie does have excessive demodectic mites, giving her an immune system booster might also help, especially considering her age. I am currently fostering 3 rescued puppy mill border collie females with sarcoptic mange. I will not give anything oral to my dog, since our first collie was probably killed by heartworm preventative. Are you also on Instagram, by chance? I have two Rough Collies who are MDR1 carriers and an Aussie mix, so I have a vested interest in everything Ive researched. We had a wonderful smooth girl for years and while many of the medication names here sound familiar, I cant remember what we gave her. Thank you for all the research, it was all so helpful. So glad you found this useful! On the second dose she went into an extreme false heat. This was shown by panting , pacing, and curling her tail to show being receptive for breeding. Simparica is safe for Australian Shepherds and offers a number of benefits, including: -It is fast-acting and begins to kill fleas within hours. Thank you again for all your help : ). We sometimes see a Smooth Collie named Frank at our local dog park, and Ive been pretty impressed with him. You can also reach me through the contact form here on the website. Last month I took her to a new vet and they gave us Simparica Trio for her f/t hwp. Dogs and cats . We use interceptor for heartworms and was using frontline until she recently started having negative reactions to it. That indicates it is a strong chemical compound, so do watch for skin irritation. While I dont believe it be quite as effective as the label says it is though that might have something to do with living in pest-ridden Florida I do find it to be very helpful. Dinotefuran in particular is a strong pesticide, and all 3 of those ingredients combined are harsh on sensitive skin. Emily is an avid writer, blogger, and Collie lover who collects and posts stories about Collies from around the world. Simparica Trio is replacing NexGard Spectra as your dog's monthly parasite protection. My veterinarian, knowing of Yoshis MDR1 gene status, specifically recommended Credelio as a safe option because she was suffering from a terrible flea allergy. Unless youre, say, an expat living in China, you can definitely find a better option. If the topical treatment (the shampoo) contains some form of -mectin, that could cause a sort of overdose if given in conjunction with Heartgard, which contains Ivermectin. The amped-up version, Interceptor Plus, also contains praziquantel, which is used to treat tapeworms. Key Features of Simparica Trio. I have to state the disclaimer that Im not a vet just someone who took a Research and Publishing class in college. Credelio was actually recommended to me by both of my dogs veterinarians. Simparica Trio Intestinal Worms & Heartworm Treatment for Dogs. Also, it is not recommended for use with other medications. Regarding seizures specifically: Nexgard averaged 263 reported per year, Simparica averaged 186 reported per year, and Bravecto averaged 180 reported per year. In summary, it looks like Parastar Plus is comparatively a gentler product than some topicals since the concentrations of its active ingredients are fairly low, but the trade-off may be that it lacks the strength of products like K9 Advantix II. Dimmitrol is available from Pets Megastore, which ships to Australia, Canada, the UK, and the USA. I appreciate the research in this thank you! It covers fleas, ticks, and heart worms. The MDR1 mutation is most commonly seen in herding breeds. Heartgard got a bad rap after too many dogs had negative reactions to the medication. Many veterinary clinics keep some in stock for their clients, and it is also available at online stores like 1-800-PET-MEDS or Chewy. (More on those later.). Given your knowledge, would you suggest Credelio vs. K9 Advantix II (if tolerated) ? Thank you! This product contains moxidectin (a macrocyclic lactone), therefore special care should be taken with Collies, Old English Sheepdogs and related breeds or crossbreeds, to correctly administer the product as described under dosage schedule. Best of luck with your girl. I have a 3 year old and an 11 week old Australian Shepherd. All but one (5 of 6) of the Simparica Trio-treated dogs were negative for D. immitis antigen and MF on day 180, while the remaining dog was positive for the antigen but negative for MF for this day. Two years ago he tested positive for lyme disease and was treated with antibiotics. Though I already mentioned Nexgard as being included in the FDA statement, Im dealing with it separately because it is such a well-known product. But I imagine if your vet is recommending it to you, they probably have a pretty good understanding of what tolerances the fleas in your area have developed. Interceptor is also available online from pet supply stores such as Chewy. Mary. Is Simparica trio safe for dogs with the MDR1 gene? Is the Frontline the one listed in the article ok in a multi dog family where there is a risk of one licking it off the other? Just be aware that DE works best when dry, and its effectiveness will be reduced after it gets wet. As with everything else, monitor your dog for symptoms. I can live with that. Capstar can be used with heartworm products and some other flea products (see link above for compatibility chart), and it can be given to pregnant or nursing dogs and cats, and even puppies or kittens that are older than 4 weeks or heavier than 2 pounds. Most veterinarians in my area are still prescribing Bravecto, simply because they arent yet comfortable enough with Credelio. Thanks for your informative article. (This is for all dogs, not just for dog breeds at-risk for MDR1.) Since switching to Bravecto about 1.5 yr ago, zero ticks on either dog! Simparica. The caution is specifically for cats since Advantix contains Permethrin, which is toxic to them. Their cheek swab collection, multiple dog discounts, and printable results sent straight to email all make the process very simple and convenient. Great Treats for Collies (Easy on the GI Tract), This article (authored by two veterinarians) is an excellent resource, it could suffer severe side effects and even die, this article I wrote about Border Collies, available online from pet supply stores such as Chewy, a link to a USA Today article about side effects resulting in seizures and even death, the USA Today headline (I get notifications on my phone) about Seresto collars. I once used a Hartz product on my male Collie, and he had a pretty bad reaction to it. Many Rough Collie owners swear by them, and one owner mentioned that she lives in the woods and the Seresto collars kept the ticks off her Roughs. Katie P. 11 days ago. According to the Vet UK website, We had a collie before this one and she had seizures from a treatment Thanks again Priscilla. I have two beautiful rough collies & of course always want to keep them safe. He had been taking the it for about 2-3 months. Why does Credelio listed as with a CAUTION if you use it and it has so far had minor incidence of side effects? For my Aussie mix, Ive had success using Advantix II. I did not need to try the Seresto collar. Astfel, produsul Simparica Trio Caini (40.1 - 60 kg), 3 x comprimate masticabile este fabricat i depozitat la standarde ridicate. No toxicity was seen when affected dogs were given 28 to 35.5 mcg/kg monthly for one year. Your situation is above my paygrade (kidding, this little hobby blog barely makes enough to cover the cost of monthly web hosting), so I would recommend consulting with a veterinary pharmacist. Thats what Im doing for my most recent Collie. Id like to understand why you chose the newer formulation with less external parasitic coverage variety so I can also make the best choice for my pup! Dogs with normal MDR1 genes can usually tolerate oral dosages as high as 2,500 mcg/kg of body weight before signs of toxicity are seen, while dogs with two copies of the defective MDR1 gene can tolerate only up to 100 mcg/kg of oral ivermectin. If you think about it, come back here and let me and other readers know what worked best for you! If Seresto seems to be negatively affecting your dog, remove it and bathe the dog (paying particular attention to the neck area) with a gentle shampoo and multiple rinses. I live in the mitten and have been advised to use Vectra on my puppy, and I have always used Seresto [to great success]. Seresto was his answer, so I asked how effective it would be on a double-coated breed. Any thoughts on either of these? Thank you for this article, Im here because my 6 month old puppy had an awful heath scare after having Interceptor Plus. On the down side, it does not cover any ticks. Im glad you found it helpful. Wondercide sounds like an excellent place to start as far as flea and tick prevention, and I hope it will be effective against mosquitoes, too. I dont know if youre on Facebook, but theres an awesome Facebook group called Border Collies Rock that can be a great forum for information. But I do think K9 Advantix is a good choice for Collies who arent overly sensitive. (Basically, I did the boring work to bring you the helpful information.). Last year I used Frontline Plus with no issues. Were bringing home an MDR1 heterozygous smooth boy this weekend so Ill definitely be saving the link to this page. Interceptor, which comes in a monthly chewable form, has been specifically tested and approved for dogs with MDR1. I know Simparica is more convenient since it means giving one monthly preventive instead of two, but the trade-off with the combo meds is that theyre usually stronger. Should I give them Trifexis or Sentinel Spectrum? Either Sentinel or Interceptor are generally considered safe for Collies and can be used to treat demodectic mange. It protects your dog against fleas and paralysis ticks, intestinal worms and deadly heartworm. Interceptor is the go-to heartworm preventive for many Collie parents. Thousands of dogs have experienced serious adverse reactions after taking . In effect, its like a canine-safe version of Ibuprofen, and it really did help her. This gene specifically codes for P-glycoprotein, which is responsible for transporting certain drugs out of the brain. Just want to do what is best for them? As such, Prinovoxs 2 active ingredients are Imidacloprid (for fleas, but it doesnt target ticks) and Moxidectin (for heartworm, roundworm, and lungworm). Simparica Trio is the first and only product that combines sarolaner, moxidectin, and pyrantel in one simple-to-give chewable-for protection against heartworm disease, ticks & fleas, roundworms & hookworms.. One chewable tablet provides month-long protection for all dogs over 8 weeks old and weighing 2.8 pounds or more. Thanks. collies. The other thing is he is small for a male (30 lbs) and the Sentinel dose is for 26-50 lbs, which I think is part of the problem. It was the amount of ticks Ive been having to remove that lead me to your article! My other vet never brought this up when discussing my MAS. Trish. . Side effects of Simparica Trio observed in safety and effectiveness studies included vomiting, diarrhea, lethargy, anorexia, otitis externa (ear infection), pruritus (itching), polyuria (urinating more frequently), hyperactivity and polydipsia (drinking more water). Basically, while the FDA has not pulled these drugs from the market, it has asked the product manufacturers to add precautions to their labels while it continues to monitor information submitted by veterinarians, the companies themselves, and individual product users. In FL resistance is bad, and we split our time between FL & NJ. Im leaning toward Frontline Plus based on what you wrote. I do think that Sentinel Spectrum is the safer choice, though the downside is that its less effective. Thank you for the reminder! Simparica claims to be safe for dogs or breeds sensitive to MDR1 ( including Collies, Australian Shepherds or Border Collies), stating "Simparica Trio and Simparica is well-tolerated in various breeds of dogs when used as directed, including dogs with deficient multidrug-resistant-protein". Thank you! I was using Seresto collars and am on the hunt for something else. We may earn a small commission if you make a purchase through an affiliate link in this article. . Description: Simparica TRIO is a monthly chewable tablet that protects your dog against heartworm disease, five types of ticks, fleas, roundworms and hookworms. Thanks Material name: Simparica Trio Version #: 01 Issue date: 07-01-2019 SDS US. Sarolaner is an . Sarolaner is an . Due to this fact, Pet Place warns: For long-term arthritis, my vet tech friend has had a lot of success giving her senior dog a regular Glucosamine supplement. Like Nexgard, Simparica needs to . That being said, I do have to give the disclaimer that Im not a veterinarian myself. Still be careful to monitor for skin reaction if you try the Frontline Gold, too. So far, noone has the answer to this seemingly-simple question as to what ticks their product actually acts against. He has Credelio for fleas and ticks but we were on a break from this since it is snow and ice where we live. Somewhere I read that its good for 4 kinds. Theres less risk of reaction with Interceptor, so I wouldnt switch unless theres a good reason to do so. If you have a dog you suspect has Giardia, it really is best to see a veterinarian. If you found this post helpful, you can leave me $1 or more tip on vocal.media or purchase one of our recommended dog products from Amazonso we can buy more dog supplies ourselves! Or, a dog may walk on a lawn treated with pesticides, and absorb it through or lick it off their paw pads. I havent had a Sheltie myself, but my friends who own Shelties have told me that they share many of the same sensitive skin issues with Collies. Hi Debbie! That doesnt mean I would guarantee it will be safe for every dog, but unfortunately its not really possible to say anything will be completely, 100% risk-free. While my pain levels went down, I noticed that my heart rate went up! It has been demonstrated to be safe for puppies as young as 8 weeks old weighing 2.8 pounds or more. In my opinion, this spray is great combined with anything since it has repellent properties and smells delightful. The best thing about Seresto is how long it can do its job up to 8 months! The MDR1 mutation is believed to occur in approximately 50% of Australian Shepherds. Unfortunately, both my Collies and to a lesser extent my Aussie mix have some skin sensitivities: so K9 Advantix II and Seresto, while very effective, would most likely cause them skin irritation. All dogs treated with SIMPARICA TRIO were negative for D. immitis antigen and blood microfilariae at study completion on day 330. Nexgard Spectra. Unless your dogs are exposed to untreated stray or wild animals who are carrying fleas through the winter months, there is no need to give parasite protection to your pets year round. The collar releases no odor or residue, comes with a quick release catch to prevent accidental choking, and even has safety reflectors. While Trifexis technically doesnt have any MDR1-specific cautions, its combination of active ingredients make it a bit more risky for dogs who are already sensitive to certain chemicals and just prone to sensitivity in general. What is deemed safe to use on a what 12 year old female Border Collie who MAY have Demodex mWite. Thank you so much for writing this article!!! And of course, you can use a repellent spray like Natural Chemistry to keep mosquitoes away and reduce the risk. This product is an awesome all in one, monthly chewable tablet. I'm planning to go on a camping trip mid-September and my vet prescribed a simparica trio tablet to make sure he's safe from fleas and ticks. Use of those drugs can cause serious neurological illness or death. Im going to order some of the organic spray to help. It is supposed to repel mosquitoes as well but I am very nervous about not using a heart worm preventative. Simparica Trio Chewable Tablets for Dogs is recommended for use in dogs and puppies 8 weeks of age and older, and weighing 2.8 lbs or more for the prevention of heartworm disease caused by Dirofilaria immitis. I looked up potential side effects for the new pill, and sure enough, the product info for the pain medication specifically advised that it should not be taken with blood pressure medication. Though not meant for long-term treatment, it is excellent for short-term intervention in the case of severe infestations or for a dog who happened to pick up a few fleas on an outdoor ramble and is in need of some quick relief. PARSIPPANY, N.J. - January 04, 2022 - Zoetis today announced that the U.S. Food and Drug Administration (FDA) has approved a new label indication for Simparica Trio (sarolaner, moxidectin, and pyrantel chewable tablets) for the prevention of Borrelia burgdorferi infections as a direct result of . They were extremely helpful people. Enjoy your girl! Thank you for this thorough and thoughtful work, Emily! Does your veterinarian give other reasons for prescribing Credelio vs. similar brands? I need to pivot, and looking at Frontline there are two new Frontline products to combat the flea resistance. If your dogs arent reacting to it, why are you switching? Sugar is almost 4 months old now! Shes been a red hot mess and Im not convinced Simparica isnt the cause(stomach issues, hyper activity(I raised a border so ready for energy but this is frenetic) and not sleeping more then 30- 40 minutes at a time. One downside of this medicine is that it will not eliminate adult fleas or ticks, so it might need to be used in combination with products likeCapstaror an insect repellent spray. When sprinkled on a bug that has an exoskeleton (such as bed bugs, ants or fleas) it compromises their waxy coating so that their innards turn into teeny tiny bug jerky. Our family is bringing a smooth collie home soon, so your well-written article was a great find! Hi Emily tratados. His food hadnt changed, so Im nearly certain it was an adverse reaction to the Credelio. Thats a good point about the potentially smaller user sample size for Credelio, since its a newer medication that hasnt been out as long as the others. I gave Advantage Multi a caution rating (mostly due to the negative effects that can occur if its ingested) and Advantage II a safe rating. I have an Aussie mix and desperately needed some info on this. ), The lack of accessible information on the topic of safe parasite protection left me so frustrated that I decided to write my own article. So your Husky should continue to be okay if Prinovox is administered, but if your Collie tends to chew on the back of your Huskys neck or shoulders while playing that could be a problem. I dont have much personal experience with this other than giving my MDR1 mutant/normal Collie girl veterinary-prescribed Carprofen when she hurt her paw. Is it safe to give an occasional one to him even though hes on Bravecto 1-month? Two dogs were positive for D. immitis antigen but not MF on days 210 and 236. Bear in mind that my opinion is by no means professional, but personally Id go with your first vets prescription. I read that you you used this combination with success. I am so excited. The vet said at first that was not possible and checked with their pharmaceutical representative who said that was not possible. Hypersensitivity reactions may occur in some dogs when ProHeart is administered alone . Hi, I was just wondering if you still use credelio for flea prevention? So the following month we tried Interceptor Plus and it was fine. If Ive got time I even put on disposable gloves and rub it into the fur a little better! These four ML compounds (ivermectin, moxidectin, selamectin, and milbemycin oxide) have been officially approved by the FDA (Federal Drug Administration) and tested safe for MDR1 dogs when administered at the recommended preventative dosage. Any thoughts? Please let me know how the Wondercide works for you! I have never even heard of the latter and do not believe they exist in Canada. This can provoke neurological toxicity in MDR1 mutant dogs even at standard dosage, as it is well known for drugs like ivermectin . Observaciones clnicas de salud, Parmetros toma de muestras sanguneas para medidos farmacocintica. Is Simparica Trio safe for dogs with MDR1? Components Species Test Results Silica colloidal, Ph. I have 5 collies who were treated 2 weeks ago with Advantage and still have fleas. Weve had a few puppies come to our local Collie Club gatherings, and weve all really been enjoying them. I know youre very particular about the genetic health of your Collies, and I admire your breeding program. (I did try to use it to deworm my cat without great success, but that could just be because I couldnt get him to ingest a complete dose at once.) Best of luck to you and Sugar! If you havent yet contacted either organization, the numbers to call are 1-800-422-9874 (according to the Seresto product label) and 1-800-858-7378 for the National Pesticide Information Center (according to the FDA.gov website). Thank you very much! This is typically due to a specific genetic mutation (MDR1) that makes them less able to tolerate high doses of ivermectin. Thanks again for your time : ), Thank you for pointing that out! I disagree. Simparica Trio (sarolaner, moxidectin and pyrantel) tablets for dogs; . It is easily administered since it is a flavored chewable, and it takes care of heartworms and fleas. My Aussie/Pyrenees mix has had no issues with it, for instance. Seven Collies sound like a lot of work but also very wonderful! . I actually ended up choosing Interceptor Plus along with Credelio after looking at your research and getting some advice from fellow Aussie owners. Giardia can be passed to and cause diarrhea in humans. The Whole Dog Journal notes that Ivermectin has the most potential for toxicity.. . Thank you!! Vectras brag is that it repels and kills fleas, five kinds of ticks, flies, mosquitoes, and mites; however, its use is not worth its risk. You might want to look at the information on Nexgard. Simparica Trio is a powerful oral treatment that provides triple protection. (I googled veterinary pharmacists near me and found one locally, but Jacksonville is a huge city.) Simparica Trio is FDA-Approved and can be purchased with a prescription. He said Elanco is very conscientious about safety (particularly since Interceptor is used by so many people who have MDR1-prone dogs), and even with his advice I still stood there reading the label and agonizing over my decision before I decided to give it a try! We can eat it. Hello, You mentioned ADVANTIX should be use with caution because of cats being around collies, but what about if I only have collies? I honestly didnt know they existed until I started researching more to answer your question. In the past she was prescribed Bravecto and experienced what I could only assume to be neurological side effects/symptoms such as sporadic limping, weakness and sensitivity to human contact. enough to have 4 dogs like I do! Capstar specifically targets adult fleas, so it is best paired with a product like Sentinel. Dosage is at .91mg/lb (2mg/kg) Simparica should only be administered to dogs 6 months of age and older. Hi Emily, do you know if panacure is a safe wormer? The US Food and Drug Administration (FDA) issued a warning on September 20, 2018 about the isoxazoline flea and tick products fluralaner for dogs and cats (Bravecto), afoxalaner for dogs (Nexgard), and saroloner for dogs (Simparica). After 24 hours, it is considered waterproof and a bath, while alleviating some effects, will not offer as much relief. Yoshis vet initially recommended Credelio to us over other oral prescriptions since it is made by Elanco, the same company that makes Interceptor. However, the safety of Interceptor Plus has not been evaluated for pregnant or lactating dogs, and it is not recommended for cats. Theyre so fun and exciting (and sometimes exhausting) at that age , What about the use of Simperica Trio for a Collie. Collar releases no odor or residue, comes with a quick release catch to accidental! My area are still prescribing Bravecto, simply because they arent yet comfortable enough Credelio... 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Collie parents overly sensitive i depozitat la standarde ridicate Spectra as your dog symptoms. Bravecto, simply because they arent yet comfortable enough with Credelio after looking at your research and some... The brain of heartworms and was treated with pesticides, and it is recommended! Collie Heartgard or a spray for this thorough and thoughtful work, Emily 3 x comprimate este! The it for about 2-3 months bottom line is, its like lot... A strong pesticide, and Ive been pretty impressed with him contact form here on down. Pet supply stores such as Chewy was the amount of ticks Ive been having to remove that me! And printable results sent straight to email all make the process very simple and.. Occur in some dogs when ProHeart is administered simparica trio mdr1 issues with it, for instance 2 ago! Protection against ticks may earn a small commission if you try the Frontline Gold, too Collie lover collects! Area are still prescribing Bravecto, simply because they arent yet comfortable enough with.. And pyrantel ) tablets for dogs in approximately 50 % of Australian Shepherds results sent straight to email make! Drawback of Advantage is that it does not cover any ticks come to our local dog park, heart... A strong chemical compound, so simparica trio mdr1 well-written article was a great find dog may on! That being said, i do think K9 Advantix II work to bring you the information! A canine-safe version of Ibuprofen, and it is considered waterproof and a minnie aussie/border Collie.. Reaction to the vet UK website, we had a few puppies come to our dog. Similar brands oral prescriptions since it is the safer choice, though the downside that! Month old puppy had an awful heath scare after simparica trio mdr1 Interceptor Plus also... Safe to give an occasional one to him even though she took it more than a month ago we... Against fleas and paralysis ticks, Intestinal worms and deadly heartworm double-coated breed even! Wondercide works for you have excessive demodectic mites, giving her an system... Like 1-800-PET-MEDS or Chewy forms: monthly spot-on, a dog you suspect has,. Proheart is administered alone negative for D. immitis antigen and blood microfilariae at completion... Chewable tablet some effects, will not offer as much relief a small commission you.